Thymidylate Synthase (5-FU Resistance Marker)

Thymidylate Synthase (5-FU Resistance Marker) is available at Gentaur for Next Week Delivery.

Product Short Name:  Thymidylate Synthase

Other Names: [Thymidylate synthase; Thymidylate synthase; thymidylate synthase; thymidylate synthetase]

Product Gene Name: [TYMS]

Other Gene Names: [TYMS; TYMS; TS; TMS; HST422; TS; TS; TSase]

Clonality:

Isotype: IgG1, kappa

Clone: [rTYMS/1884]

Host: Mouse

Reactivity: Human

Specifity: It recognizes a protein of 36kDa, identified as Thymidylate Synthase (TS) (EC 2.1.1.45). It converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is also a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein has been reported to associate with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.

Purity:  Purified Ab with BSA and Azide at 200ug/ml OR Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Form: 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA at 1.0mg/ml.

Concentration: 

Storage Stability:  Antibody with azide: store at 2 to 8 degree C. Antibody is stable for 24 months.,Non-hazardous. No MSDS required.

Tested Application:  ELISA (EIA), Flow Cytometry (FC/FACS), Immunofluorescence (IF)