SIRT6 Antibody

SIRT6 Antibodyis available at Gentaur for Next week Delivery.

Description: Human Sirtuins function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. Sirtuin 6 (SIRT6) is a NAD-dependent protein deacetylase with activity towards Lys-9 and Lys-56 of histone H3. It modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. It is required for genomic stability and for normal IGF1 serum levels and normal glucose homeostasis. It also regulates cellular senescence and apoptosis. Unlike most sirtuins, SIRT6 preferentially removes long-chain fatty-acyl, rather than acetyl, protein modifications. This activity regulates secretion of the inflammation-associated protein TNF-α.

Immunogen Sequence:Recombinant Human Sirtuin 6 (Cat # 7699)

Target Alternative Name:SIRT6, NAD-dependent Deacetylase Sirtuin-6; Mono-ADP-ribosyltransferase Sirtuin 6; SIR2-like Protein 6; SIR2L6

Species Reactivities:Human, Mouse

Tag Line:Polyclonal Antibody to detect Sirt6 in human and Mouse samples

Formulation:30 µg (0.5 mg/ml) of antibody in PBS pH 7.2, 0.01 % BSA, 0.03 % ProClin®, and 50 % glycerol.

Purification: Affinity Purified Antibody

Application:Western blot

Positive Control:Western Blot: Jurkat cell lysate, mouse muscle lysate, Rat kidney lysate, Recombinant proteins

Application And Usages:Western blot: 1-4 µg

Handling:The antibody solution should be gently mixed before use.