Phospho-VAV3 (Tyr173) Antibody

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SKU:
A1713-100
Availability:
Next week delivery
  • Phospho-VAV3 (Tyr173) Antibody
  • Phospho-VAV3 (Tyr173) Antibody
$1,535.31
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Description

Phospho-VAV3 (Tyr173) Antibodyis available at Gentaur for Next week Delivery.

Description: Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). May be important for integrin-mediated signaling, at least in some cell types. In osteoclasts, along with SYK tyrosine kinase, required for signaling through integrin alpha-v/beta-1 (ITAGV-ITGB1), a crucial event for osteoclast proper cytoskeleton organization and function. This signaling pathway involves RAC1, but not RHO, activation. Necessary for proper wound healing. In the course of wound healing, required for the phagocytotic cup formation preceding macrophage phagocytosis of apoptotic neutrophils. Responsible for integrin beta-2 (ITGB2)-mediated macrophage adhesion and, to a lesser extent, contributes to beta-3 (ITGB3)-mediated adhesion. Does not affect integrin beta-1 (ITGB1)-mediated adhesion

Immunogen Sequence:A synthesized peptide derived from human VAV3 around the phosphorylation site of Tyrosine 173.

Target Alternative Name:Guanine nucleotide exchange factor VAV3, VAV-3

Species Reactivities:Mouse, Human

Tag Line:Polyclonal antibody to detect endogenous levels of VAV3 (Tyr173) in human and mouse samples

Formulation:In phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Purification: Affinity purified

Application:Western Blotting, ELISA

Positive Control:/

Application And Usages:WB 1:500-1:2000, ELISA (peptide) 1:20000-1:40000

Handling:The antibody solution should be gently mixed before use.

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Additional Information

Size:
100 µl
Antibody Target:
Guanine nucleotide exchange factor VAV3
Category:
Phospho-Specific
Host:
Rabbit
Antibody Type:
Polyclonal
Isotype:
IgG
Concentration:
1 mg/ml
Appearance:
Colorless liquid
Form:
Liquid
Storage Condition:
-20ºC
Shipping Condition:
Gel Pack
Shelf Life:
12 months
Country of Animal Origin:
USA
Country of Manufacture:
USA
Usage:
For Research Use Only! Not to be used in humans.
Western Blot Verified:
VRAI
Immunocytochemistry Verified:
FAUX
Immunofluorescence Verified:
FAUX
Immunoprecipitation Verified:
FAUX
FACS Verified:
FAUX
ELISA Verified:
VRAI
ChIP Verified:
FAUX
Dot Blot Verified:
FAUX
Flow Cytometry Verified:
FAUX
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