Phospho-VAV3 (Tyr173) Antibody

Phospho-VAV3 (Tyr173) Antibodyis available at Gentaur for Next week Delivery.

Description: Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). May be important for integrin-mediated signaling, at least in some cell types. In osteoclasts, along with SYK tyrosine kinase, required for signaling through integrin alpha-v/beta-1 (ITAGV-ITGB1), a crucial event for osteoclast proper cytoskeleton organization and function. This signaling pathway involves RAC1, but not RHO, activation. Necessary for proper wound healing. In the course of wound healing, required for the phagocytotic cup formation preceding macrophage phagocytosis of apoptotic neutrophils. Responsible for integrin beta-2 (ITGB2)-mediated macrophage adhesion and, to a lesser extent, contributes to beta-3 (ITGB3)-mediated adhesion. Does not affect integrin beta-1 (ITGB1)-mediated adhesion

Immunogen Sequence:A synthesized peptide derived from human VAV3 around the phosphorylation site of Tyrosine 173.

Target Alternative Name:Guanine nucleotide exchange factor VAV3, VAV-3

Species Reactivities:Mouse, Human

Tag Line:Polyclonal antibody to detect endogenous levels of VAV3 (Tyr173) in human and mouse samples

Formulation:In phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Purification: Affinity purified

Application:Western Blotting, ELISA

Positive Control:/

Application And Usages:WB 1:500-1:2000, ELISA (peptide) 1:20000-1:40000

Handling:The antibody solution should be gently mixed before use.