Phospho-Retinoic Acid Receptor alpha (Ser77) Antibody

Phospho-Retinoic Acid Receptor alpha (Ser77) Antibodyis available at Gentaur for Next week Delivery.

Description: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation

Immunogen Sequence:A synthesized peptide derived from human Retinoic Acid Receptor alpha around the phosphorylation site of Sersine 77

Target Alternative Name:Retinoic acid receptor alpha, RAR-alpha, Nuclear receptor subfamily 1 group B member 1, RARA, NR1B1

Species Reactivities:Rat, Mouse, Human

Tag Line:Polyclonal antibody to detect endogenous levels of Phospho-Retinoic Acid Receptor alpha (Ser77)

Formulation:In phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02% sodium azide and 50% glycerol

Purification: Affinity purified

Application:Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC), Western Blotting

Positive Control:/

Application And Usages:WB 1:500-1:2000 IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA (peptide) 1:20000-1:40000

Handling:The antibody solution should be gently mixed before use.