Phospho-Cyclin E1 (Thr77) Antibody

Phospho-Cyclin E1 (Thr77) Antibodyis available at Gentaur for Next week Delivery.

Description: Cyclin E1 is a regulatory subunit of the CDK2 kinase. It is central for the regulation of the G1/S transition and its abundance is tightly regulated throughout the cell cycle via ubiquitination. Cyclin E has been the subject of intense study in relation to tumorigenesis and cancer management and prognosis. Multiple isoforms of Cyclin E are only expressed in tumors but not in normal tissue, suggesting a post transcriptional regulation of Cyclin E. In vitro analyses indicated that these truncated variant isoforms of Cyclin E are able to phosphorylate histone H1. Alterations in the Cyclin E protein have been implicated as indicators of worse prognosis in various cancers.

Immunogen Sequence:KLH-conjugated synthetic peptide encompassing a sequence within the center region of human Cyclin E1

Target Alternative Name:CCNE; G1/S-specific cyclin-E1

Species Reactivities:Human, Mouse

Tag Line:Polyclonal antibody to detect endogenous levels of Cyclin E1 (pT77) in human and monkey.

Formulation:In 0.42% Potassium phosphate; 0.87% Sodium chloride; pH 7.3; 30% glycerol and 0.01% sodium azide

Purification: Affinity purified

Application:WB, IH, IF/IC

Positive Control:WB: HEK293; IHC: human heart tissue; IFC: HEK293 cells

Application And Usages:WB; 1:500 – 1:2000, IHC; 1:50 – 1:200, IF/IC; 1:50 – 1:100

Handling:The antibody solution should be gently mixed before use