Phospho-Chk2 (Ser516) Antibody

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SKU:
A1264-100
Availability:
Next week delivery
  • Phospho-Chk2 (Ser516) Antibody
  • Phospho-Chk2 (Ser516) Antibody
£208.54
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Description

Phospho-Chk2 (Ser516) Antibodyis available at Gentaur for Next week Delivery.

Description: Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Following activation, phosphorylates numerous effectors preferentially at the consensus sequence [L-X-R-X-X-S/T]. Regulates cell cycle checkpoint arrest through phosphorylation of CDC25A, CDC25B and CDC25C, inhibiting their activity. Inhibition of CDC25 phosphatase activity leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression.

Immunogen Sequence:Synthesized peptide derived from human Chk2 around the phosphorylation site of S516

Target Alternative Name:Serine/threonine-protein kinase Chk2, CHK2 checkpoint homolog, Cds1 homolog, Hucds1, hCds1, Checkpoint kinase 2, CHEK2

Species Reactivities:Human, Monkey

Tag Line:Polyclonal antibody to detect endogenous levels of Chk2 (pS516) in human and monkey samples

Formulation:In PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide

Purification: Affinity-chromatography using epitope-specific immunogen

Application:WB, ELISA

Positive Control:WB: COS 7 cell lysate

Application And Usages:WB 1:500-1:2000; ELISA 1:10000

Handling:The antibody solution should be gently mixed before use

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Additional Information

Size:
100 µl
Antibody Target:
CHEK2
Category:
Cell Cycle
Lot Number:
N/A
Host:
Rabbit
Antibody Type:
Polyclonal
Isotype:
Rabbit IgG
Accession Number:
O96017
Gene Id:
11200
Appearance:
Colorless liquid
Form:
Liquid
Storage Condition:
-20°C
Shipping Condition:
gel pack
Shelf Life:
12 months
Country of Animal Origin:
USA
Country of Manufacture:
USA
Usage:
For Research Use Only! Not to be used in humans
Western Blot Verified:
Verified
Immunocytochemistry Verified:
Not Verified
Immunofluorescence Verified:
Not Verified
Immunoprecipitation Verified:
Not Verified
FACS Verified:
Not Verified
ELISA Verified:
Not Verified
ChIP Verified:
Not Verified
Dot Blot Verified:
Not Verified
Flow Cytometry Verified:
Not Verified
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