Phospho-Cdk2 (Thr160) Antibody

Phospho-Cdk2 (Thr160) Antibodyis available at Gentaur for Next week Delivery.

Description: Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Interacts with cyclins A, B1, B3, D, or E. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus.

Immunogen Sequence:Synthesized peptide derived from human Cdk2 around the phosphorylation site of T160.

Target Alternative Name:Cyclin-dependent kinase 2, Cell division protein kinase 2, p33 protein kinase, CDK2, CDKN2

Species Reactivities:Human, Mouse, Rat

Tag Line:Polyclonal antibody to detect endogenous levels of Cdk2 (pT160) in human, mouse and rat samples

Formulation:In PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide

Purification: Affinity-chromatography using epitope-specific immunogen

Application:WB, ELISA, IHC

Positive Control:WB: HeLa cell lysate

Application And Usages:WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:5000

Handling:The antibody solution should be gently mixed before use