Phospho-Caveolin-1 (Tyr14) Antibody

Phospho-Caveolin-1 (Tyr14) Antibodyis available at Gentaur for Next week Delivery.

Description: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation.

Immunogen Sequence:Synthesized peptide derived from human Caveolin-1 around the phosphorylation site of Tyr14. AA: 1-80

Target Alternative Name:Caveolin-1, CAV1, CAV

Species Reactivities:Human, Mouse, Rat

Tag Line:Polyclonal antibody to detect endogenous levels of Caveolin-1 (pTyr14) in human, mouse and rat samples

Formulation:In PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide

Purification: Affinity-chromatography using epitope-specific immunogen

Application:WB, ELISA

Positive Control:WB: HeLa cell, A549 cell lysate

Application And Usages:WB 1:500-1:2000; ELISA 1:5000

Handling:The antibody solution should be gently mixed before use