Phospho-BRCA1 (Ser1457) Antibody

Phospho-BRCA1 (Ser1457) Antibodyis available at Gentaur for Next week Delivery.

Description: E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for normal cell cycle progression from G2 to mitosis. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage.

Immunogen Sequence:A synthesized peptide derived from human BRCA1 around the phosphorylation site of Sersine 1457

Target Alternative Name:Breast cancer type 1 susceptibility protein, RING finger protein 53, RING-type E3 ubiquitin transferase BRCA1, RNF53

Species Reactivities:Human

Tag Line:Polyclonal antibody to detect endogenous levels of Phospho-BRCA1 (Ser1457)

Formulation:In phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Purification: Affinity purified

Application:Western Blotting, ELISA

Positive Control:/

Application And Usages:WB 1:500-1:2000, ELISA (peptide) 1:20000-1:40000

Handling:The antibody solution should be gently mixed before use.