Phospho-BRCA1 (Ser1457) Antibody

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SKU:
A1719-100
Availability:
Next week delivery
  • Phospho-BRCA1 (Ser1457) Antibody
  • Phospho-BRCA1 (Ser1457) Antibody
£289.03
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Description

Phospho-BRCA1 (Ser1457) Antibodyis available at Gentaur for Next week Delivery.

Description: E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for normal cell cycle progression from G2 to mitosis. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage.

Immunogen Sequence:A synthesized peptide derived from human BRCA1 around the phosphorylation site of Sersine 1457

Target Alternative Name:Breast cancer type 1 susceptibility protein, RING finger protein 53, RING-type E3 ubiquitin transferase BRCA1, RNF53

Species Reactivities:Human

Tag Line:Polyclonal antibody to detect endogenous levels of Phospho-BRCA1 (Ser1457)

Formulation:In phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Purification: Affinity purified

Application:Western Blotting, ELISA

Positive Control:/

Application And Usages:WB 1:500-1:2000, ELISA (peptide) 1:20000-1:40000

Handling:The antibody solution should be gently mixed before use.

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Additional Information

Size:
100 µl
Antibody Target:
Breast cancer type 1 susceptibility protein
Category:
phospho-specific
Host:
Rabbit
Antibody Type:
Polyclonal
Isotype:
IgG
Accession Number:
P38398
Gene Id:
672
Concentration:
1 mg/ml
Appearance:
Colorless liquid
Form:
Liquid
Storage Condition:
-20°C
Shipping Condition:
Gel Pack
Shelf Life:
12 months
Country of Animal Origin:
USA
Country of Manufacture:
USA
Usage:
For Research Use Only! Not to be used in humans.
Western Blot Verified:
VRAI
Immunocytochemistry Verified:
FAUX
Immunofluorescence Verified:
FAUX
Immunoprecipitation Verified:
FAUX
FACS Verified:
FAUX
ELISA Verified:
VRAI
ChIP Verified:
FAUX
Dot Blot Verified:
FAUX
Flow Cytometry Verified:
FAUX
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