Nucleophosmin (Acute Myeloid Leukemia Marker)

Nucleophosmin (Acute Myeloid Leukemia Marker) is available at Gentaur for Next Week Delivery.

Product Short Name:  Nucleophosmin

Other Names: [nucleophosmin isoform 3; Nucleophosmin; nucleophosmin; nucleophosmin 1; Nucleolar phosphoprotein B23; Nucleolar protein NO38; Numatrin]

Product Gene Name: [NPM1]

Other Gene Names: [NPM1; NPM1; B23; NPM; NPM; NPM]

Clonality:

Isotype: IgG1, kappa

Clone: [rNPM1/1901]

Host: Mouse

Reactivity: Human

Specifity: Recognizes a 33kDa glycoprotein, identified as Nucleophosmin (NPM). It is predominantly localized in the nucleus of cells in most tissues. NPM is involved in ribosomal assembly and rRNA transport. It is an abundant protein that is highly phosphorylated by Cdc2 kinase during mitosis. This phosphoprotein moves between the nucleus and the cytoplasm. It is thought to be involved in several processes including regulation of the ARF/p53 pathway. A number of genes are fusion partners, in particular the anaplastic lymphoma kinase gene on chromosome 2. Mutations in exon 12 affecting the C-terminus of the protein are associated with an aberrant cytoplasmic location. Mutations in this gene are associated with acute myeloid leukemia. The antibody may be a useful aid for classification of acute myeloid leukemia.

Purity:  Purified Ab with BSA and Azide at 200ug/ml OR Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Form: 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Concentration: 

Storage Stability:  Antibody with azide: store at 2 to 8 degree C.
Antibody without azide: store at -20 to -80 degree C.
Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Tested Application:  Immunohistochemistry (IHC) Paraffin