HTRA1 Antibody

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SKU:
CAF20273
Availability:
Next week delivery
£24,073.65
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Description

HTRA1 Antibodyis available at Gentaur for next week delivery.

Specificity: 5654

Alternative Names:

Immunogen: A synthesized peptide derived from human HTRA1.

Technical Notes: Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. This activity requires the integrity of the catalytic site, although it is unclear whether TGF-beta proteins are themselves degraded. By acting on TGF-beta signaling, may regulate many physiological processes, including retinal angiogenesis and neuronal survival and maturation during development. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets.

Application: WB

Restriction:

Comments: Ice packs

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Additional Information

Species Reactivity:
Human,Mouse,Rat
Size:
100ug
Host:
Rabbit
Clonality:
Polyclonal
Concentration:
HTRA1
Storage:
1mg/ml
Expiry Date:
-20°C
Shipping Condition:
1 year
Uniprot:
Q92743
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