Description
ECD Antibodyis available at Gentaur for next week delivery.
Specificity: 11319
Alternative Names:
Immunogen: A synthesized peptide derived from human ECD.
Technical Notes: Regulator of p53/TP53 stability and function. Inhibits MDM2-mediated degradation of p53/TP53 possibly by cooperating in part with TXNIP (PubMed:16849563, PubMed:23880345). May be involved transcriptional regulation. In has intrinsic transactivation activity enhanced by EP300. May be a transcriptional activator required for the expression of glycolytic genes (PubMed:19919181, PubMed:9928932). Involved in regulation of cell cycle progression. Proposed to disrupt Rb-E2F binding leading to transcriptional activation of E2F proteins (PubMed:19640839). The cell cycle -regulating function may depend on its RUVBL1-mediated association with the R2TP complex (PubMed:26711270). May play a role in regulation of pre-mRNA splicing (PubMed:24722212).
Application: WB
Restriction:
Comments: Ice packs
Additional Information
Species Reactivity: |
Human,Mouse |
Size: |
100ug |
Host: |
Rabbit |
Clonality: |
Polyclonal |
Concentration: |
ECD |
Storage: |
1mg/ml |
Expiry Date: |
-20°C |
Shipping Condition: |
1 year |
Uniprot: |
O95905 |