Description
DOCK8 Antibodyis available at Gentaur for next week delivery.
Specificity: 81704
Alternative Names:
Immunogen: A synthesized peptide derived from human DOCK8.
Technical Notes: Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP (PubMed:28028151, PubMed:22461490). During immune responses, required for interstitial dendritic cell (DC) migration by locally activating CDC42 at the leading edge membrane of DC (By similarity). Required for CD4+ T-cell migration in response to chemokine stimulation by promoting CDC42 activation at T cell leading edge membrane (PubMed:28028151). Is involved in NK cell cytotoxicity by controlling polarization of microtubule-organizing center (MTOC), and possibly regulating CCDC88B-mediated lytic granule transport to MTOC during cell killing (PubMed:25762780).
Application: WB
Restriction:
Comments: Ice packs
Additional Information
Species Reactivity: |
Human,Mouse,Rat |
Size: |
100ug |
Host: |
Rabbit |
Clonality: |
Polyclonal |
Concentration: |
DOCK8 |
Storage: |
1mg/ml |
Expiry Date: |
-20°C |
Shipping Condition: |
1 year |
Uniprot: |
Q8NF50 |
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