Cathepsin D Antibody

(No reviews yet) Write a Review
SKU:
3191R-30T
Availability:
Next week delivery
  • Cathepsin D Antibody
  • Cathepsin D Antibody
  • Cathepsin D Antibody
$345.93
Frequently bought together:

Description

Cathepsin D Antibodyis available at Gentaur for Next week Delivery.

Description: Cathepsin D is a normal lysosomal protease that is expressed in all cells. It is an aspartyl protease with a pH optimum in the range of 3-5, and contains two N-linked oligosaccharides. Cathepsin D is synthesized as an inactive 52 kDa pro-enzyme. Activation involves the proteolytic removal of the 43 amino acid profragment and an internal cleavage to generate the two-chain form made up of 34 and 14 kDa subunits. Cathepsin D contains the mannose-6-phosphate lysosomal localization signal that targets the enzyme to the lysosomal compartment where it functions in the normal degradation of proteins. In certain tumor cells, Cathepsin D is abnormally processed and is secreted in its 52 kDa precursor form. Numerous clinical studies as well as in vitro evidence sμggest that cathepsin D plays an important role in malignant transformation and may be a useful prognostic indicator for breast cancer.

Immunogen Sequence:Synthetic peptide surrounding amino acid 140 of mouse cathepsins D

Target Alternative Name:CTSD , CLN10, CPSD, mgC2311

Species Reactivities:Human, mouse, rat

Tag Line:/

Formulation:30 µg (0.5 mg/ml) affinity purified rabbit anti-cathepsin D polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.

Purification: Affinity purified

Application:Western blot

Positive Control:/

Application And Usages:Western blot analysis (0.5-4 µg/ml) and in immunoprecipitation. However, the optimal conditions should be determined individually. The purified antibody detects both the 52 kDa proform and the 34 kDa cleaved fragment of Cathepsin D.

Handling:The antibody solution should be gently mixed before use.

View AllClose

Additional Information

Size:
30 µg
Antibody Target:
Cathepsin D
Category:
Cathepsin
Lot Number:
50991R
Host:
Rabbit
Antibody Type:
Polyclonal
Isotype:
Rabbit IgG
Accession Number:
EDL18143
Gene Id:
13033
Concentration:
0.5 mg/ml
Appearance:
Colorless liquid
Form:
Liquid
Storage Condition:
-20 °C
Shipping Condition:
gel pack
Shelf Life:
12 months
Country of Animal Origin:
China
Country of Manufacture:
USA
Usage:
For Research Use Only! Not to be used in humans.
Western Blot Verified:
Verified
Immunocytochemistry Verified:
Not Verified
Immunofluorescence Verified:
Not Verified
Immunoprecipitation Verified:
Not Verified
ELISA Verified:
Not Verified
ChIP Verified:
Not Verified
Flow Cytometry Verified:
Not Verified
View AllClose

0 Reviews

View AllClose