Caspase-2 Antibody

Caspase-2 Antibodyis available at Gentaur for Next week Delivery.

Description: Caspases play a key role in apoptosis. Similar as other caspases, caspase-2 is also synthesized as an inactive pro-enzyme that is processed in cells undergoing apoptosis. Caspase-2 mRNA is alternatively spliced. The larger mRNA species encoding a product of 435 amino acids is known as ICH-1L. The smaller mRNA species encoding a protein of 312 amino acids is named ICH-1S. Over expression of ICH-1L induces apoptosis, while over expression of ICH-1S suppresses Rat-1 cell death induced by serum deprivation.

Immunogen Sequence:Synthetic peptide surrounding amino acid 417 of mouse caspase-2

Target Alternative Name:CASP-2, NEDD-2,NEDD2, ICH1, ICH-1L/1S, ICH-1L, EC 3.4.22.55

Species Reactivities:Human, mouse, rat

Tag Line:/

Formulation:30 µg (0.2 mg/ml) affinity purified rabbit anti-caspase-2 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal

Purification: Affinity purified

Application:Western blot, Immunohistochemistry

Positive Control:Western Blot: Jurkat cell lysate, treated and untreated. IHC: Placenta tissue.

Application And Usages:Western blotting (1-2 µg/ml), and Immunohistochemistry (5 µg/ml). However, the optimal conditions should be determined individually. Detects the full length and small subunit of caspase-2. In human samples, it also detects a 30 kDa intermeadiate fragment

Handling:The antibody solution should be gently mixed before use.