BRD2 Antibody

BRD2 Antibodyis available at Gentaur for Next week Delivery.

Description: The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. A bromodomain is a protein domain that recognizes acetylated lysine residues such as those on the N-terminal tails of histones. This recognition is often a prerequisite for protein-histone association and chromatin remodeling. These domains function in the linking of protein complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. Thus, bromodomains serve as “readers” of histone acetylation marks regulating the transcription of target promoters. The BET family of proteins, defined by tandem Bromodomains and an Extra Terminal domain, include BRD2, BRD3, BRD4, and BRDT. The BET proteins play a key role in many cellular processes, including inflammatory gene expression, mitosis, and viral/host interactions. The isolated individual or tandem bromodomains of BRD2 and BRD4 have been shown to bind acetylated histone tails, serving to couple histone acetylation marks to the transcriptional regulation of target promoters. Small molecule inhibitors of these interactions hold promise as useful therapeutics for human disease.

Immunogen Sequence:Synthetic peptide at N-terminal

Target Alternative Name:RING3, RNF3; Bromodomain containing 4

Species Reactivities:Human, mouse, rat

Tag Line:Rabbit polyclonal antibody to detect BRD2 in human mouse and rat samples.

Formulation:30 µg (0.5 mg/ml) of antibody in PBS, 0.01 % BSA, 0.01 % thimerosal, and 50 % glycerol, pH 7.2

Purification: Affinity purified antibody

Application:Western blot

Positive Control:Western blot: 3T3 cell lysate

Application And Usages:Western blot: 1:200

Handling:The antibody solution should be gently mixed before use.