Bcl-xL Antibody

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SKU:
3312-30T
Availability:
Next week delivery
  • BCL-XL Antibody
  • BCL-XL Antibody
  • Bcl-xL Antibody
  • Bcl-xL Antibody
$88
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Description

Bcl-xL Antibodyis available at Gentaur for Next week Delivery.

Description: Bcl-xL is a 30 kDa anti-apoptotic protein belonging to the Bcl-2 family. Bcl-xL prevents apoptosis throμgh two different mechanisms: by heterodimerization with an apoptotic protein to inhibit its apoptotic effect, and by its direct pore-forming effect on the outer-membrane of mitochondria to help maintain a normal membrane state under stress conditions. Bcl-xL can be cleaved by caspases upon apoptotic activation, which converts Bcl-xL from an antiapoptotic protein to a proapoptotic cleavage product. The cleavage product of Bcl-xL forms cytochrome c-releasing pores in the mitochondrial membrane to facilitate the apoptosis signaling pathway.

Immunogen Sequence:Synthetic peptide surrounding amino acid 56 of human Bcl-xL

Target Alternative Name:Bcl-xL, Bcl-xS, BCL2L1, BCL2-like 1 protein

Species Reactivities:Human, mouse, rat

Tag Line:/

Formulation:30 µg (0.5 mg/ml) affinity purified, rabbit anti-Bcl-xL polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.

Purification: Affinity purified

Application:Western blot, Immunoprecipitation

Positive Control:/

Application And Usages:Western blotting (0.5-4 µg/ml) and immunoprecipitation (20 µ/ml). However, the optimal conditions should be determined individually. The antibody detects the 30 kDa Bcl-xL protein. It does not react with other Bcl-2 family members.

Handling:The antibody solution should be gently mixed before use.

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Additional Information

Size:
30 µg
Antibody Target:
Bcl-xl
Category:
Bcl-2
Lot Number:
51112
Host:
Rabbit
Antibody Type:
Polyclonal
Isotype:
Rabbit IgG
Accession Number:
Q92934
Gene Id:
572
Concentration:
0.5 mg/ml
Appearance:
Colorless liquid
Form:
Liquid
Storage Condition:
-20 °C
Shipping Condition:
gel pack
Shelf Life:
12 months
Country of Animal Origin:
China
Country of Manufacture:
USA
Usage:
For Research Use Only! Not to be used in humans.
Western Blot Verified:
Verified
Immunocytochemistry Verified:
Not Verified
Immunofluorescence Verified:
Not Verified
Immunoprecipitation Verified:
Not Verified
ELISA Verified:
Not Verified
ChIP Verified:
Not Verified
Flow Cytometry Verified:
Not Verified
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