ATG4C Polyclonal Antibody

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SKU:
CAC09527
Availability:
Next week delivery
£24,439.51
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Description

ATG4C Polyclonal Antibodyis available at Gentaur for next week delivery.

Specificity:

Alternative Names: Q96DT6

Immunogen: Recombinant Human Cysteine protease ATG4C protein (419-448AA)

Technical Notes: For Research Use Only. Not for use in diagnostic procedures, drug use, or for administration to humans or animals.

Application: ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200

Restriction:

Comments: Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, PH 7.4; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Is not essential for autophagy development under normal conditions but is required for a proper autophagic response under stressful conditions such as prolonged starvation (By similarity). Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms.

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Additional Information

Species Reactivity:
Human
Size:
100ug
Host:
Rabbit
Clonality:
Polyclonal
Concentration:
-20°C
Storage:
1 year
Expiry Date:
Ice packs
Shipping Condition:
Conjugation service and the corresponding secondary antibody are available.
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