TUCAN/CARD8 Antibody

TUCAN/CARD8 Antibodyis available at Gentaur for Next week Delivery.

Description: TUCAN (Tumor Up-regulated Card-containing Antagonist of Caspase-Nine) is a CARD (Caspase-Associated Recruitment Domains) containing protein that binds and suppresses activation of pro-Caspase-9 and found to be overexpressed in some types of cancers. TUCAN binds specifically to pro-caspase-9 and interferes with its interaction with Apaf-1, thereby suppressing apoptosis signaling in the mitochondrial/cytochrome c pathway.

Immunogen Sequence:Synthetic peptide surrounding amino acid 420 of human TUCAN

Target Alternative Name:DACAR , NDPP1 , TUCAN , CARDINAL , KIAA0955 , mgC57162 , DKFZp779L0366

Species Reactivities:Human, mouse, rat

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Formulation:30 µg (0.2 mg/ml) Protein A affinity purified rabbit anti-TUCAN polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5 BSA and 0.01% thimerosal.

Purification: Affinity purified

Application:Western blot

Positive Control:/

Application And Usages:Western blotting (0.5-4 µg/ml). However, the optimal conditions should be determined individually. The antibody detects 47 kDa TUCAN in samples from human, mouse, and rat origins. Jurkat cell lysate, mouse small intestine and rat kidney tissue lysates can be used as positive controls.

Handling:The antibody solution should be gently mixed before use.