SREBP1 Antibody

SREBP1 Antibodyis available at Gentaur for Next week Delivery.

Description: SREBP (Sterol Regulatory Element Binding Protein) 1 and 2 are transcription factors th at regulates cholesterol homeostasis. SREBP proteins are attached to the endoplasmic reticulum and nuclear envelope. SREBP proteins undergo proteolytic cleavage in response to conditions of low cellular sterol. Upon activation of SREBP 1, a soluble NH2 cleavage fragment translocate to the nucleus and activates transcription of enzymes and other proteins required for cholesterol synthesis.

Immunogen Sequence:Synthetic peptide surrounding amino acid 318 of rat SREBP1

Target Alternative Name:Adipocyte determination- and differentiation-dependent factor 1, ADD1, Sterol regulatory element-binding transcription factor 1

Species Reactivities:Human, mouse, rat

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Formulation:30 µg (0.5 mg/ml) affinity purified rabbit anti-SREBP1polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 5 mM EDTA and 0.01% thimerosal.

Purification: Affinity purified

Application:Western blot

Positive Control:Jurkat (Induced and Uninduced), Rat Kidney, 3T3 cell lysates

Application And Usages:The antibody can be used for Western blot analysis (0.5-4 µg/ml). However, the optimal conditions should be determined individually. Blocking peptide (Cat.# 3961BP-50) is available separately.

Handling:The antibody solution should be gently mixed before use.