Smac/DIABLO Antibody

Smac/DIABLO Antibodyis available at Gentaur for Next week Delivery.

Description: Smac/DIABLO is a mitochondrial protein that is released along with cytochrome c during apoptosis and activates cytochrome c/Apaf-1/caspase-9 pathway. Smac/DIABLO binds to IAPs (Inhibitor of Apoptosis Proteins) and neutralizes the inhibitory effect of IAPs. Analysis of the structural basis of Smac/DIABLO has revealed that the N-terminal amino acids are required for Smac/DIABLO to bind to IAPs and activation of caspases.

Immunogen Sequence:Synthetic peptide surrounding amino acid 220 of mouse Smac/DIABLO

Target Alternative Name:SMAC, SMAC3, DIABLO, DIABLO-S , FLJ10537, FLJ25049, 0610041G12Rik

Species Reactivities:Human, mouse, rat

Tag Line:/

Formulation:In phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 5 mM EDTA and 0.03% proclin.

Purification: Affinity purified

Application:Western blot, Immunohistochemistry

Positive Control:/

Application And Usages:Western blotting (0.5-4 µg/ml) and Immunohistochemistry (5-20 µg/ml). However, the optimal conditions should be determined individually. The immunoaffinity purified antibody detects the 25 kDa Smac/DIABLO in samples from human, mouse, and rat origins.

Handling:The antibody solution should be gently mixed before use.