SHANK3 Antibody (Center)

SHANK3 Antibody (Center)is available at Gentaur for Next week Delivery.

Description: SH3 and multiple ankyrin repeat domains 3 (SHANK3), a member of the Shank gene family, plays a role in synapse formation and dendritic spine maturation. Shank proteins (Shank 1-3) containing PDZ domains are scaffold proteins of the postsynaptic density (PSD) that connect neurotransmitter receptors and ion channels proteins to the actin cytoskeleton and G-protein-coupled signaling pathways. Transcript splice variation in the Shank family influences the spectrum of Shank-interacting proteins in the PSDs of adult and developing brain to ensure normal development. Mutations of SHANK3 are a cause of autism spectrum disorder (ASD) and the neurological symptoms of 22q13.3 deletion syndrome.

Immunogen Sequence:SHANK3 antibody was raised against a 19 amino acid synthetic peptide near the center of human SHANK3.

Target Alternative Name:SH3 and multiple ankyrin repeat domains 3, ProSAP2, PSAP2, SPANK-2, Proline-rich synapse-associated protein 2

Species Reactivities:Human, Mouse

Tag Line:/

Formulation:100 µg (1 mg/ml) in 1X PBS containing 0.02 % sodium azide.

Purification: Affinity chromatography purified via peptide column

Application:Western blot, IHC, ELISA

Positive Control:Western Blot:3T3 cell Lysate IHC: Human brain tissue

Application And Usages:Western Blot: 1 μg/ml, IHC: 2.5 μg/ml, ELISA. However, the optimal conditions should be determined individually.

Handling:The antibody solution should be gently mixed before use.