Runx1/AML1-ETO polyclonal antibody

Runx1/AML1-ETO polyclonal antibodyis available at Gentaur for Next week Delivery.

Description: This antibody specifically recognizes the AML1 (RUNX1) - ETO (RUNX1T1) fusion protein that arises due to a translocation between chromosome 8 and 22 (t(8;21)(q22;q22)). This translocation is one of the most frequent karyotypic abnormalities observed in acute myeloid leukemia. It produces a chimerical gene made up of the 5’-region of AML1and the 3’-region of ETO. The chimerical protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation.

Immunogen Sequence:Polyclonal antibody raised in rabbit against the Runx1-ETO fusion protein using a KLH-conjugated synthetic peptide.

Target Alternative Name:AML1-ETO

Species Reactivities:Human.

Tag Line:Polyclonal Antibody to detect Runx1-ETO in human, mouse and a wide range of samples.

Formulation:In PBS with 0.05% (W/V) sodium azide.

Purification: Whole Anti-Sera

Application:Western blot, ELISA, ChIP.

Positive Control:Western blot: SKNO-1 cells, ELISA: Peptides, ChIP: Kasumi cells.

Application And Usages:ChIP: 4 µg/ChIP, WB: 1:1000, ELISA: 1:500

Handling:The antibody solution should be gently mixed before use.