ROR2 Antibody (NT)

ROR2 Antibody (NT)is available at Gentaur for Next week Delivery.

Description: ROR2 (receptor tyrosine kinase-like orphan receptor 2), also known as neurotrophic tyrosine kinase receptor-related 2 (NTRKR2), is a single pass transmembrane tyrosine-protein kinase receptor. It contains a cytoplasmic tyrosine kinase domain, distally located serine-threonine-rich domains, an extracellular immunoglobulin-like domain, a cysteine-rich domain and a kringle domain. ROR2 is important for skeletal and endocrine development and is required for cartilage and growth plate development. It promotes the differentiation of osteoblasts and plays an important role in the early formation of chondrocytes. ROR2 may play differential roles during the development of the nervous system. ROR2 sequesters and associates with Dlxin-1 affecting the transcriptional function of Msx-2. ROR2 also interacts with canonical Wnt1 and Wnt3, regulating their signaling pathways. Defects in ROR2 can result in the autosomal dominant skeletal disorder, brachydactylic type B1 or the autosomal recessive skeletal disorder, Robinow syndrome.

Immunogen Sequence:This ROR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 19-50 amino acids from the N-terminal region of human ROR2.

Target Alternative Name:ROR2, NTRKR2, Tyrosine-protein kinase transmembrane receptor ROR2; Neurotrophic tyrosine kinase, receptor-related 2

Species Reactivities:Human

Tag Line:Polyclonal Antibody to detect ROR2 in human samples

Formulation:100 µl of antibody in PBS with 0.09% (W/V) sodium azide

Purification: This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

Application:Western blot, Immunohistochemistry, FACS

Positive Control:Western Blot: 293 cell lysate, IHC: Paraffin embedded human kidney carcinoma, FACS: NCI-H292

Application And Usages:Western blot: 1:1000, IHC: 1:10 to 1:50, FACS: 1:10 to 1:50

Handling:The antibody solution should be gently mixed before use.