RhoGDI Antibody

RhoGDI Antibodyis available at Gentaur for Next week Delivery.

Description: Controls Rho proteins homeostasis. Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Retains Rho proteins such as CDC42, RAC1 and RHOA in an inactive cytosolic pool, regulating their stability and protecting them from degradation. Actively involved in the recycling and distribution of activated Rho GTPases in the cell, mediates extraction from membranes of both inactive and activated molecules due its exceptionally high affinity for prenylated forms. Through the modulation of Rho proteins, may play a role in cell motility regulation. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1.

Immunogen Sequence:KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human RhoGDI alpha

Target Alternative Name:GDIA1, Rho GDP-dissociation inhibitor 1, Rho GDI 1, Rho-GDI

Species Reactivities:Human

Tag Line:Polyclonal antibody to detect endogenous levels of RhoGDI in human samples.

Formulation:In 0.42% Potassium phosphate; 0.87% Sodium chloride; pH 7.3; 30% glycerol and 0.01% sodium azide

Purification: Affinity purified

Application:WB, IH

Positive Control:WB:A549, DLD, HepG2 cell lysates; IHC: human breast cancer tissue

Application And Usages:WB; 1:500 – 1:2000, IHC; 1:50 – 1:200

Handling:The antibody solution should be gently mixed before use