RASSF1A Antibody

RASSF1A Antibodyis available at Gentaur for Next week Delivery.

Description: RASSF1A is one of the most epigenetically silenced gene in human cancers and an important negative regulator of NFkB activation and potential tumor suppressor. It is required for death receptor-dependent apoptosis. It also mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation. When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Isoform A interacts with CDC20, an activator of the anaphase-promoting complex, APC, resulting in the inhibition of APC activity and mitotic progression. RASSF1A inhibits proliferation by negatively regulating cell cycle progression at the level of G1/S-phase transition by regulating accumulation of cyclin D1 protein. Isoform C has been shown not to perform these roles; no function has been identified for this isoform. Isoform A disrupts interactions among MDM2, DAXX and USP7, thus contributing to the efficient activation of TP53 by promoting MDM2 self-ubiquitination in cell-cycle checkpoint control in response to DNA damage.

Immunogen Sequence:Full length protein

Target Alternative Name:Ras association domain-containing protein 1, 123F2, NORE2A, RASSF1, RDA32, REH3P21

Species Reactivities:Human, Mouse

Tag Line:Monoclonal antibody to detect endogenous levels ofRASSF1A in human and mouse.

Formulation:In 0.42% Potassium phosphate; 0.87% Sodium chloride; pH 7.3; 30% glycerol and 0.01% sodium azide

Purification: Affinity purified

Application:WB, IH, IP

Positive Control:WB; HCT116, ModeK, 4T1 cell lysate, mouse colon tissue, IH: mouse and human colon tissue

Application And Usages:WB- 1:50, IHC- 1:50, IP- 1.5 µg

Handling:The antibody solution should be gently mixed before use