PSGL-1 Antibody

PSGL-1 Antibodyis available at Gentaur for Next week Delivery.

Description: PSGL-1 (P-Selectin glycoprotein ligand, also designated CD162), exists as a disulfide-linked homodimer. PSGL-1 is a type 1 membrane protein that localizes on the tips of microvilli of leukocytes. Its extracellular domain is rich in serines, threonines and prolines, and includes a series of 15 and 16 decameric repeats in HL-60 and U-937 cells, and human leukocytes, respectively. Although PSGL-1 appears to be the sole receptor for P-Selectin on human hematopoietic cells, it also interacts with E-Selectin through a unique binding site. In order to bind PSGL-1 to either E-Selectin or P-Selectin, PSGL-1 must be sialylated and fucosylated. PSLG-1 is a mucin-like molecule, much like leukosialin (CD43), CD164 and CD34. These proteins belong to an emerging family of cell adhesion receptors called sialomucins, which transduce negative signals in hematopoietic cells.

Immunogen Sequence:Synthetic peptide near C-terminal (BV-L31-32)

Target Alternative Name:PSGL, CD162, SELPLG, CLA, CD162, PSGL1, Selectin P ligand.

Species Reactivities:Human, mouse, rat

Tag Line:Polyclonal Antibody to detect PSGL-1 in human, mouse and rat samples

Formulation:100 µg (0.5 mg/ml) of antibody in PBS pH 7.2 containing 0.01 % BSA, 0.01 % thimerosal, and 50 % glycerol.

Purification: Affinity Purified Antibody

Application:Western blot

Positive Control:Western blot: Jurkat Cell lysate

Application And Usages:Western blot: 1-4 µg/ml.

Handling:The antibody solution should be gently mixed before use.