Phospho-VEGFR2 (Tyr-1214) Polyclonal Antibody

Phospho-VEGFR2 (Tyr-1214) Polyclonal Antibodyis available at Gentaur for Next week Delivery.

Description: Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. Plays an essential role in the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis. Promotes proliferation, survival, migration and differentiation of endothelial cells. Promotes reorganization of the actin cytoskeleton. Isoforms lacking a transmembrane domain, such as isoform 2 and isoform 3, may function as decoy receptors for VEGFA, VEGFC and/or VEGFD. Isoform 2 plays an important role as negative regulator of VEGFA- and VEGFC-mediated lymphangiogenesis by limiting the amount of free VEGFA and/or VEGFC and preventing their binding to FLT4. Modulates FLT1 and FLT4 signaling by forming heterodimers. Binding of vascular growth factors to isoform 1 leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C

Immunogen Sequence:Synthetic peptide

Target Alternative Name:VEGFR-2, FLK-1, KDR, CD309

Species Reactivities:Human

Tag Line:Polyclonal antibody to detect VEGFR2 (phospho-T1214) in human samples.

Formulation:100 ug (1 mg/ml) of antibody in 0.01M Tris-HCl, pH 8.0, 0.15M NaCl, and 0.02% sodium azide.

Purification: Affinity purified rabbit IgG using protein G

Application:WB, Immunoblot, ELISA

Positive Control:N/A

Application And Usages:Western blot, Immunoblot: 0.5-2 μg/ml, ELISA

Handling:The antibody solution should be gently mixed before use