Phospho-Stat2 Antibody

Phospho-Stat2 Antibodyis available at Gentaur for Next week Delivery.

Description: Membrane receptor signaling by various ligands induces activation of Jak kinases which then leads to tyrosine phosphorylation of the various Stat transcription factors. Stat1 and Stat2 are induced by IFN-α and form a heterodimer which is part of the ISGF3 transcription factor complex. Althoμgh early reports indicate Stat3 activation by EGF and IL-6, it has been shown that Stat3β appears to be activated by both while Stat3α is activated by EGF, but not by IL-6. Highest expression of Stat4 is seen in testis and myeloid cells. IL-12 has been identified as an activator of Stat4. Stat5 is activated by prolactin and by IL-3. Stat6 is involved in IL-4 activated signaling pathways.

Immunogen Sequence:Synthetic peptide corresponding to resides around amino acid 686 of mouse Stat2

Target Alternative Name:STAT2 , ISGF-3 , P113 , p113 , STAT113 , mgC59816

Species Reactivities:Human, mouse

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Formulation:100 µg (0.5 mg/ml) immunoaffinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 50% glycerol, 1% BSA, and 0.02% thimerosal.

Purification: Affinity purified

Application:Western blot

Positive Control:/

Application And Usages:Western blotting (1-4 µg/ml). However, the optimal concentrations should be determined individually. The antibody recognizes ~113 kDa phosphorylated Stat2 (Tyr689) of human and mouse origins. Reactivity to other species has not been tested.

Handling:The antibody solution should be gently mixed before use.