Phospho (Ser19) Tyrosine Hydroxylase Antibody

Phospho (Ser19) Tyrosine Hydroxylase Antibodyis available at Gentaur for Next week Delivery.

Description: Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the synthesis of the catecholamines Dopamine and Norepinephrine. TH antibodies can therefore be used as markers for dopaminergic and noradrenergic neurons in a variety of applications including depression, schizophrenia, Parkinson’s disease and drμg abuse (Kish et al., 2001; Zhu et al., 2000; Zhu et al., 1999). TH antibodies can also be used to explore basic mechanisms of dopamine and norepinephrine signaling (Witkovsky et al., 2000; Salvatore et al., 2001; Dunkley et al., 2004). The activity of TH is also regulated by phosphorylation (Haycock et al., 1982; Haycock et al., 1992; Jedynak et al., 2002). Phospho-specific antibodies for the phosphorylation sites on TH can be used to great effect in studying this regulation and in identifying the cells in which TH phosphorylation occurs.

Immunogen Sequence:Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser19 of rat tyrosine hydroxylase.

Target Alternative Name:TH; TYH; Tyrosine hydroxylase

Species Reactivities:Mammalian, rat

Tag Line:/

Formulation:100 μl in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 μg per ml BSA and 50% glycerol.

Purification: Affinity purified

Application:Western blot, Immunoprecipitation, Immunofluorescence

Positive Control:/

Application And Usages:The antibody can be used for Western blotting (1:1000), Immunofluorescence (1:1000) and Immunohistochemistry (1:1000). However, the optimal conditions should be determined individually.

Handling:The antibody solution should be gently mixed before use.