Phospho-PKC ζ (Thr 410) Antibody

Phospho-PKC ζ (Thr 410) Antibodyis available at Gentaur for Next week Delivery.

Description: Calcium- and diacylglycerol-independent serine/threonine-protein kinase that functions in phosphatidylinositol 3-kinase (PI3K) pathway and mitogen-activated protein (MAP) kinase cascade, and is involved in NF-kappa-B activation, mitogenic signaling, cell proliferation, cell polarity, inflammatory response and maintenance of long-term potentiation (LTP). Upon lipopolysaccharide (LPS) treatment in macrophages, or following mitogenic stimuli, functions downstream of PI3K to activate MAP2K1/MEK1-MAPK1/ERK2 signaling cascade independently of RAF1 activation. Required for insulin-dependent activation of AKT3, but may function as an adapter rather than a direct activator. Upon insulin treatment may act as a downstream effector of PI3K and contribute to the activation of translocation of the glucose transporter SLC2A4/GLUT4 and subsequent glucose transport in adipocytes.

Immunogen Sequence:Synthesized peptide derived from human PKC ζ around the phosphorylation site of Thr 410.

Target Alternative Name:PRKCZ; PKC2; Protein kinase C zeta type; nPKC-zeta

Species Reactivities:Human, mouse and rat

Tag Line:Polyclonal antibody to detect Phospho-PKC ζ (Thr 410) in human, mouse and rat samples.

Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide

Purification: Affinity-purified using epitope specific immunogen.

Application:WB, IHC, IF, ELISA

Positive Control:WB: 823, Hela, PC-3, MCF-7, 22RV1 cell lysate

Application And Usages:WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:20000

Handling:The antibody solution should be gently mixed before use.