Phospho LIMK1/2 (Thr508/505) Antibody

Phospho LIMK1/2 (Thr508/505) Antibodyis available at Gentaur for Next week Delivery.

Description: There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein is ubiquitously expressed during development and plays a role in many cellular processes associated with cytoskeletal structure. This protein also stimulates axon growth and may play a role in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Immunogen Sequence:KLH-conjugated synthetic peptide targeting a sequence within the C-term region of human LIMK1/2

Target Alternative Name:LIMK; LIM domain kinase 1; LIMK-1

Species Reactivities:Bovine, Rat, Chicken, Human

Tag Line:Affinity purified rabbit polyclonal antibody to detect phosphorylation of LIMK1/2 at Thr508/505 in human, rat, bovine and chicken samples

Formulation:In 0.42% Potassium phosphate; 0.87% NaCl; pH 7.3; 30% glycerol; and 0.01% sodium azide

Purification: Affinity purified

Application:Immunohistochemistry (IHC), Immunofluorescence (IF), Western Blotting

Positive Control:/

Application And Usages:WB 1:500 - 1:1000, IHC 1:100 - 1:200, IF 1:100 - 1:500

Handling:The antibody solution should be gently mixed before use.