Phospho-LC3C(S12) Antibody

Phospho-LC3C(S12) Antibodyis available at Gentaur for Next week Delivery.

Description: Autophagy is an alternative process of proteasomal degradation for some long-lived proteins or organelles. Alterations in the autophagic-lysosomal compartment have been linked to neuronal death in many neurodegenerative disorders as well as in transmissible neuronal pathologies (prion diseases). Genetic studies in yeast have shown that Autophagy-defective Gene-8 (Atg-8) represents a specific marker for autophagy. Among the four families of mammalian Atg8-related proteins only LC3 (Microtubule-associated Protein1 Light Chain 3) is expressed at sufficient high levels and efficiently recruited to autophagic vesicles in cells and tissues. During autophagy the cytoplasmic form, LC3-I is processed and recruited to autophagosomes, where LC3-II is generated by site specific proteolysis near to the C-terminus. Autophagic vacuoles have been also reported frequently in cardiomyopathies or muscle cells exposed to different experimental settings.

Immunogen Sequence:This LC3C Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S12 of human LC3C.

Target Alternative Name:MAP1LC3A; Microtubule-associated proteins 1A/1B light chain 3A; Autophagy-related protein LC3 A; Autophagy-related ubiquitin-like modifier LC3 A; MAP1 light chain 3-like protein 1; Microtubule-associated protein 1 light chain 3 alpha

Species Reactivities:Human. Predicted cross reactivity with bovine, mouse and rat samples.

Tag Line:Polyclonal antibody to detect Phospho-LC3C in human samples

Formulation:Supplied in PBS with 0.09% (W/V) sodium azide.

Purification: Affinity Purified Antibody

Application:Western Blot, Dot Blot

Positive Control:WB: SH-SY5Y cells, Dot blot: Phospho and non-phospho peptides

Application And Usages:WB: ~1:1000, DB: 1:500.

Handling:The antibody solution should be gently mixed before use.