Description
Phospho-JKK1/SEK1/MKK4 Antibodyis available at Gentaur for Next week Delivery.
Description: SAPK/Erk kinase (SEK1), also known as MKK4 or Jun kinase kinase (JNKK), activates the MAP kinase homologues SAPK and JNK in response to various cellular stresses and inflammatory cytokines. Activation of SEK1 occurs throμgh phosphorylation of serine and threonine residues at positions 257 and 261, respectively, by MEKK. Like MEK, SEK is a dual-specificity protein kinase that phosphorylates SAPK/JNK at a conserved T*PY* site in its activation loop. Phosphorylation by Akt at Ser80 inhibits SEK1 and suppresses the stress-activated signal transduction.
Immunogen Sequence:Synthetic peptide surrounding Ser80 of human SEK1/MKK4
Target Alternative Name:MAP2K4, SERK1, MAPKKA, JNKK1, PRKMK4, MEK4
Species Reactivities:Human, mouse, rat
Tag Line:/
Formulation:100 µg (0.5 mg/ml) peptide affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 50% glycerol, 1% BSA, and 0.02% thimerosal.
Purification: Affinity purified
Application:Western blot
Positive Control:/
Application And Usages:Western blotting (1-4 µg/ml). However, the optimal concentrations should be determined individually. The antibody recognizes phosphorylated SEK1/MKK4/JKK1 of human, mouse, and rat origins.
Handling:The antibody solution should be gently mixed before use.
Additional Information
Size: |
100 µg |
Antibody Target: |
Phospho-SEK1/MKK4 |
Category: |
JKK/SEK/MKK4 |
Lot Number: |
51278 |
Host: |
Rabbit |
Antibody Type: |
Polyclonal |
Isotype: |
Rabbit IgG |
Accession Number: |
P45985 |
Gene Id: |
6416 |
Concentration: |
0.5 mg/ml |
Appearance: |
Colorless liquid |
Form: |
Liquid |
Storage Condition: |
-20 °C |
Shipping Condition: |
gel pack |
Shelf Life: |
12 months |
Country of Animal Origin: |
China |
Country of Manufacture: |
USA |
Usage: |
For Research Use Only! Not to be used in humans. |
Western Blot Verified: |
Verified |
Immunocytochemistry Verified: |
Not Verified |
Immunofluorescence Verified: |
Not Verified |
Immunoprecipitation Verified: |
Not Verified |
ELISA Verified: |
Not Verified |
ChIP Verified: |
Not Verified |
Flow Cytometry Verified: |
Not Verified |