Phospho-Glucocorticoid Receptor (Ser203) Antibody

Phospho-Glucocorticoid Receptor (Ser203) Antibodyis available at Gentaur for Next week Delivery.

Description: Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling. Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth.

Immunogen Sequence:A synthesized peptide derived from human GR around the phosphorylation site of Sersine 203.

Target Alternative Name:Glucocorticoid receptor, GR, Nuclear receptor subfamily 3 group C member 1, NR3C1, GRL

Species Reactivities:Mouse, Human

Tag Line:Polyclonal antibody to detect endogenous levels of Phospho-Glucocorticoid Receptor (Ser203)

Formulation:In phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol

Purification: Affinity purified

Application:Immunofluorescence (IF), Immunocytochemistry (ICC), Western Blotting, ELISA

Positive Control:/

Application And Usages:WB 1:500-1:2000, IF/ICC 1:100-1:500, ELISA (peptide) 1:20000-1:40000

Handling:The antibody solution should be gently mixed before use.