Phospho-FoxO1 (Ser319) antibody

Phospho-FoxO1 (Ser319) antibodyis available at Gentaur for Next week Delivery.

Description: Forkhead box O (FoxO) transcription factors are downstream targets of the serine/threonine protein kinase B (PKB)/Akt. The Akt kinase regulates processes of cellular proliferation and survival. Within the family, three members (FoxO1, FoxO4, and FoxO3a) have sequence similarity to the nematode orthologue DAF-16, which mediates signaling via a pathway involving IGFR1, PI3K, and Akt. The FoxO signaling is regulated by their interactions with other intracellular proteins as well as their post-translational modifications such as phosphorylation. Increased proliferation results when forkhead transcription factors are inactivated through phosphorylation by Akt at Thr24, Ser256, and Ser319, which results in nuclear export and inhibition of transcription factor activity

Immunogen Sequence:Synthesized peptide derived from human FoxO1 around the phosphorylation site of S319

Target Alternative Name:FOXO1; FKHR; FOXO1A; Forkhead box protein O1; Forkhead box protein O1A; Forkhead in rhabdomyosarcoma

Species Reactivities:Human, Mouse, Rat

Tag Line:Polyclonal antibody to detect FoxO1 (Phospho-Ser319) in human, mouse and Rat samples

Formulation:100 ug (1 mg/ml) of antibody in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide

Purification: Affinity purified rabbit IgG

Application:WB, IHC, ELISA

Positive Control:Western blot

Application And Usages:WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000

Handling:The antibody solution should be gently mixed before use