Description
Phospho-FoxO1 (Ser319) antibodyis available at Gentaur for Next week Delivery.
Description: Forkhead box O (FoxO) transcription factors are downstream targets of the serine/threonine protein kinase B (PKB)/Akt. The Akt kinase regulates processes of cellular proliferation and survival. Within the family, three members (FoxO1, FoxO4, and FoxO3a) have sequence similarity to the nematode orthologue DAF-16, which mediates signaling via a pathway involving IGFR1, PI3K, and Akt. The FoxO signaling is regulated by their interactions with other intracellular proteins as well as their post-translational modifications such as phosphorylation. Increased proliferation results when forkhead transcription factors are inactivated through phosphorylation by Akt at Thr24, Ser256, and Ser319, which results in nuclear export and inhibition of transcription factor activity
Immunogen Sequence:Synthesized peptide derived from human FoxO1 around the phosphorylation site of S319
Target Alternative Name:FOXO1; FKHR; FOXO1A; Forkhead box protein O1; Forkhead box protein O1A; Forkhead in rhabdomyosarcoma
Species Reactivities:Human, Mouse, Rat
Tag Line:Polyclonal antibody to detect FoxO1 (Phospho-Ser319) in human, mouse and Rat samples
Formulation:100 ug (1 mg/ml) of antibody in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide
Purification: Affinity purified rabbit IgG
Application:WB, IHC, ELISA
Positive Control:Western blot
Application And Usages:WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000
Handling:The antibody solution should be gently mixed before use
Additional Information
Size: |
100µl |
Antibody Target: |
FoxO1 (Ser319) |
Category: |
Apoptosis |
Host: |
Rabbit |
Antibody Type: |
Polyclonal |
Isotype: |
Rabbit IgG |
Accession Number: |
Q12778 (Human) |
Gene Id: |
2308 (Human) |
Concentration: |
1 mg/ml |
Appearance: |
Colorless liquid |
Form: |
Liquid |
Storage Condition: |
-20°C |
Shipping Condition: |
gel pack |
Shelf Life: |
12 months |
Country of Animal Origin: |
USA |
Country of Manufacture: |
USA |
Usage: |
For Research Use Only! Not to be used in humans |
Western Blot Verified: |
Verified |
Immunocytochemistry Verified: |
Not Verified |
Immunofluorescence Verified: |
Not Verified |
Immunoprecipitation Verified: |
Not Verified |
ELISA Verified: |
Not Verified |
ChIP Verified: |
Not Verified |
Dot Blot Verified: |
Not Verified |
Flow Cytometry Verified: |
Not Verified |