Phospho-BRCA1 Antibody

Phospho-BRCA1 Antibodyis available at Gentaur for Next week Delivery.

Description: BRCA1 is a breast cancer susceptibility gene that was localized to chromosome 17q. Mutations within this gene are believed to account for approximately 45% of families with high incidence of breast cancer and at least 80% of families with increased incidence of both early-onset breast cancer and ovarian cancer. The BRCA1 gene is expressed in numerous tissues, including breast and ovary, and encodes a predicted protein of 1863 amino acids. Like many other genes involved in familial cancer, BRCA1 appears to encode a tumor suppressor, a protein that acts as a negative regulator of tumor growth.

Immunogen Sequence:Phosphorylated synthetic peptide surrounding Serine 1189 of human BRCA1

Target Alternative Name:BRCA1, BRCA pSer 1280, Breast Cancer Gene 1, Breast Cancer 1, Early Onset; Breast-Ovarian Cancer Susceptibility

Species Reactivities:Human

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Formulation:100 µg (0.5 mg/ml) peptide affinity purified rabbit anti-phosphorylated BRCA1 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA, 0.02% thimerosal.

Purification: Affinity purified

Application:Western blot

Positive Control:/

Application And Usages:Western blotting (1-2 µg/ml). However, the optimal conditions should be determined individually. Other applications have not been tested yet. Detect human BRCA1 when phosphorylated at Ser1189.

Handling:The antibody solution should be gently mixed before use.