Phospho-BID (Ser78) Antibody

Phospho-BID (Ser78) Antibodyis available at Gentaur for Next week Delivery.

Description: Bid, a BH3 domain-containing proapoptotic Bcl-2 family member, is localized in the cytosolic fraction of cells as an inactive precursor. Its active form is generated upon proteolytic cleavage by caspase-8 in the Fas signaling pathway. Cleaved Bid translocates to mitochondria and releases its potent proapoptotic activity, which in turn induces cytochrome c release and mitochondrial damage. The cytochrome c releasing activity of Bid was antagonized by Bcl-2. Mutation in the SH3 domain can diminish the cytochrome c releasing activity. In the animal model studies, Bid-deficient mice are found resistant to the lethal effects of death factor signals relayed through Fas.

Immunogen Sequence:KLH-conjugated synthetic peptide encompassing a sequence within the center region of human BID

Target Alternative Name:BH3-interacting domain death agonist, p22 BID, BID

Species Reactivities:Human, Mouse

Tag Line:Polyclonal antibody to detect endogenous levels of BID (pSer78) in human, mouse and rat samples.

Formulation:In 0.42% Potassium phosphate; 0.87% Sodium chloride; pH 7.3; 30% glycerol and 0.01% sodium azide

Purification: Affinity purified

Application:WB, IH

Positive Control:WB: mouse spleen, rat spleen lysates; IHC: human brain tissue

Application And Usages:WB; 1:500 – 1:2000, IHC; 1:50 – 1:200

Handling:The antibody solution should be gently mixed before use