Phospho-Bad Antibody

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SKU:
3269-100
$322
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Description

Phospho-Bad Antibodyis available at Gentaur for Next week Delivery.

Description: Bad is a member of the Bcl-2 family protein that selectively dimerize with Bcl-xL and Bcl-2 resulting in cell death. Survival factors such as IL-3 can inhibit the apoptotic activity of Bad by activating intracellular signaling pathways that result in the phosphorylation of Bad at Ser112 and Ser 136. Phosphorylation at these sites results in the binding of Bad to 14-3-3 proteins and the inhibition of Bad binding to Bcl-xL and Bcl-2. Recently, Akt has also been shown to promote cell survival via its ability to phosphorylate Bad at Ser136.

Immunogen Sequence:Synthetic phospho-peptide corresponding to residues surrounding Ser112 of mouse Bad

Target Alternative Name:BAD,phospho BBC2, phosphoBBC6, BAD (Phospho-Ser112),BCL2L8

Species Reactivities:Human, mouse, rat

Tag Line:/

Formulation:100 µg (0.2 mg/ml) peptide affinity purified rabbit anti-Phospho-Bad (Ser112) polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA, 0.02% thimerosal.

Purification: Affinity purified

Application:Western blot, Immunoprecipitation, Immunohistochemistry

Positive Control:/

Application And Usages:Western blot analysis (1-2 µg/ml) and immunoprecipitation (5-20 µg/ml). However, the optimal conditions should be determined individually. The antibody detects 23 kDa Bad only when phosphorylated at Ser112.

Handling:The antibody solution should be gently mixed before use.

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Additional Information

Size:
100 µg
Antibody Target:
Bad
Category:
Bad
Lot Number:
51069
Host:
Rabbit
Antibody Type:
Polyclonal
Isotype:
Rabbit IgG
Accession Number:
Q61337.1
Gene Id:
2493288
Concentration:
0.2 mg/ml
Appearance:
Colorless liquid
Form:
Liquid
Storage Condition:
-20 °C
Shipping Condition:
gel pack
Shelf Life:
12 months
Country of Animal Origin:
China
Country of Manufacture:
USA
Usage:
For Research Use Only! Not to be used in humans.
Western Blot Verified:
Verified
Immunocytochemistry Verified:
Not Verified
Immunofluorescence Verified:
Not Verified
Immunoprecipitation Verified:
Not Verified
ELISA Verified:
Not Verified
ChIP Verified:
Not Verified
Flow Cytometry Verified:
Not Verified
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