Phospho-ATF-2 Antibody

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SKU:
3359-100
$1,263.23
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Description

Phospho-ATF-2 Antibodyis available at Gentaur for Next week Delivery.

Description: The transcription factor ATF-2 (also called CRE-BP1) is a member of the ATF/CREB family of leucine zipper proteins. ATF-2 forms homodimers and heterodimers with c-Jun to initiate CRE-dependent transcription. Phosphorylation of ATF-2 at Thr69 and Thr71 by stress-activated kinases is necessary for transcriptional activation. Myc also induces phosphorylation of ATF-2 at Thr69 and Thr71 to prolong the half-life of ATF-2. ATF-2 also functions as a histone acetyltransferase (HAT) by specifically acetylating histones H2B and H4 in vitro.

Immunogen Sequence:Synthetic phospho-peptide corresponding to residues surrounding Thr71 of human ATF2

Target Alternative Name:ATF2, HB16, CREB2, CREBP1, CRE-BP1, CRE-BP1, TREB7, mgC111558, Cyclic AMP-dependent transcription factor ATF-2, Activating transcription factor 2, Cyclic AMP-dependent transcription factor ATF-2; cAMP-dependent transcription factor ATF-2; Activating transcription factor 2; cAMP response element-binding protein CRE-BP1; HB16; Cyclic AMP-responsive element-binding protein 2; cAMP-responsive element-binding protein 2; CREB-2.

Species Reactivities:Human, mouse, rat

Tag Line:/

Formulation:100 µg (0.5 mg/ml) purified rabbit anti-Phospho-ATF-2 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA, 0.02% thimerosal.

Purification: Affinity purified

Application:Western blot, Immunoprecipitation, Immunohistochemistry

Positive Control:/

Application And Usages:Western blotting (1-4 µg/ml), immunoprecipitation (10 µg/ml), and Immunohistochemistry (20 µg/ml). However, the optimal conditions should be determined individually. The antibody detects phosphorylated ATF-2. It recognizes both Thr69/Thr71 dually phosphoralated ATF-2 as well as ATF-2 singly phosphorylated ATF-2 in samples of human, mouse, and rat origins.

Handling:The antibody solution should be gently mixed before use.

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Additional Information

Size:
100 µg
Antibody Target:
Phospho-ATF-2 (Thr71)
Category:
ATF-2
Lot Number:
51159
Host:
Rabbit
Antibody Type:
Polyclonal
Isotype:
Rabbit IgG
Accession Number:
P15336
Gene Id:
215274241
Concentration:
0.5 mg/ml
Appearance:
Colorless liquid
Form:
Liquid
Storage Condition:
-20 °C
Shipping Condition:
gel pack
Shelf Life:
12 months
Country of Animal Origin:
China
Country of Manufacture:
USA
Usage:
For Research Use Only! Not to be used in humans.
Western Blot Verified:
Verified
Immunocytochemistry Verified:
Not Verified
Immunofluorescence Verified:
Not Verified
Immunoprecipitation Verified:
Not Verified
ELISA Verified:
Not Verified
ChIP Verified:
Not Verified
Flow Cytometry Verified:
Not Verified
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