Phospho-ASK 1 (Ser83) Antibody

Phospho-ASK 1 (Ser83) Antibodyis available at Gentaur for Next week Delivery.

Description: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaling for determination of cell fate such as differentiation and survival. Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation. MAP3K5/ASK1 is required for the innate immune response, which is essential for host defense against a wide range of pathogens. Mediates signal transduction of various stressors like oxidative stress as well as by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF) or lipopolysaccharide (LPS). Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K4/SEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs). Both p38 MAPK and JNKs control the transcription factors activator protein-1 (AP-1).

Immunogen Sequence:Synthesized peptide derived from human ASK 1 around the phosphorylation site of S83. AA range: 20-100

Target Alternative Name:Apoptosis signal-regulating kinase 1, Mitogen-activated protein kinase kinase kinase 5, ASK-1, MAPK/ERK kinase kinase 5, MEK kinase 5, MEKK 5

Species Reactivities:Human

Tag Line:Polyclonal antibody to detect endogenous levels of ASK 1 (pSer83) in human samples

Formulation:In PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide

Purification: Affinity-chromatography using epitope-specific immunogen

Application:WB, ELISA, IHC

Positive Control:WB: 293 cell lysate

Application And Usages:WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000;

Handling:The antibody solution should be gently mixed before use