Phospho-AMPKα1 (Ser496) Antibody

Phospho-AMPKα1 (Ser496) Antibodyis available at Gentaur for Next week Delivery.

Description: Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. Acts as a key regulator of cell growth and proliferation by phosphorylating TSC2, RPTOR and ATG1/ULK1: in response to nutrient limitation, negatively regulates the mTORC1 complex by phosphorylating RPTOR component of the mTORC1 complex and by phosphorylating and activating TSC2.

Immunogen Sequence:Synthesized peptide derived from human AMPKα1 around the phosphorylation site of S496 (420-500aa)

Target Alternative Name:PRKAA1; AMPK1; 5'-AMP-activated protein kinase catalytic subunit alpha-1; AMPK subunit alpha-1; Acetyl-CoA carboxylase kinase; ACACA kinase; Hydroxymethylglutaryl-CoA reductase kinase; H mgCR kinase; Tau-protein kinase PRKAA1

Species Reactivities:Human, mouse , rat

Tag Line:Polyclonal antibody to detect endogenous levels of AMPKα1 protein when phosphorylated at Ser496 in human, mouse and rat.

Formulation:In PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide

Purification: Affinity-chromatography using epitope-specific immunogen

Application:WB, ELISA, IHC

Positive Control:WB: HeLa cell lysate

Application And Usages:WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000

Handling:The antibody solution should be gently mixed before use