Phospho-AMPKβ1 (Ser182) Antibody

Phospho-AMPKβ1 (Ser182) Antibodyis available at Gentaur for Next week Delivery.

Description: Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).

Immunogen Sequence:Synthesized peptide derived from human AMPKβ1 around the phosphorylation site of S182.

Target Alternative Name:PRKAB1; AMPK; 5'-AMP-activated protein kinase subunit beta-1; AMPK subunit beta-1; AMPKb

Species Reactivities:Human, mouse , rat

Tag Line:Polyclonal antibody to detect endogenous levels of AMPKβ1 protein when phosphorylated at Ser182 in human, mouse and rat.

Formulation:In PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide

Purification: Affinity-chromatography using epitope-specific immunogen

Application:WB, ELISA, IHC

Positive Control:WB: COLO205 cell lysate

Application And Usages:WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:40000

Handling:The antibody solution should be gently mixed before use