PARP Antibody (Clone 7A10)

PARP Antibody (Clone 7A10)is available at Gentaur for Next week Delivery.

Description: PARP, a 116 kDa nuclear poly (ADP-ribose) polymerase, appears to be involved in DNA repair in response to environmental stress. This protein can be cleaved by many ICE-like Caspases in vitro and is one of the main cleavage targets of caspase-3 in vivo. In human PARP, the cleavage occurs between Asp214 and Gly215, which separates the PARP amino-terminal DNA binding domain (24 kDa) from the carboxy-terminal catalytic domain (89 kDa). PARP helps cells to maintain their viability; cleavage of PARP facilitates cellular disassembly and serves as a marker of cells undergoing apoptosis.

Immunogen Sequence:N/A

Target Alternative Name:PARP, PPOL, ADPRT, ADPRT1, PARP-1, pADPRT-1, PARP1

Species Reactivities:Human

Tag Line:/

Formulation:N/A

Purification: N/A

Application:Western blot, Immunocytochemistry

Positive Control:Jurkat (1), K562 (2), HeLa (3), Raji (4), THP-1 (5) and SW620 (6) cell lysate.

Application And Usages:The antibody performs well on Western blot (1:500-1:2000) and Flow Cytometry studies (1:200-1:400).

Handling:The antibody solution should be gently mixed before use.