P-glycoprotein Antibody

P-glycoprotein Antibodyis available at Gentaur for Next week Delivery.

Description: P-gp, also called MDR1 or ABCB1, is a glycoprotein that in humans is encoded by the ABCB1 gene. P-gp is a well-characterized ABC-transporter (which transports a wide variety of xenobiotics across extra- and intracellular membranes). It is an ATP-dependent drug efflux pump with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein functions in the kidneys, liver, blood–brain barrier and the intestinal epithelium.

Immunogen Sequence:Synthetic peptide corresponding to amino acids around position 630 of human P-glycoprotein

Target Alternative Name:P-gp, Multidrug resistance protein 1, MDR1, ATP-binding cassette sub-family B (MDR/TAP) member 1, ABCB1

Species Reactivities:Human, Mouse, Rat

Tag Line:Polyclonal antibody to detect P-glycoprotein in human, mouse, rat samples

Formulation:Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg NaN3

Purification: Immunogen affinity purified antibody

Application:IHC-P, IHC-F

Positive Control:IHC: Mouse Kidney, Mouse Intestine, Rat Kidney, Human Lung Cancer tissue

Application And Usages:IHC: 1:500-1:1000 of 0.5 mg/ml stock

Handling:The vial should be centrifuged to collect the lyophilized solid before reconstituting