Noggin Antibody

Noggin Antibodyis available at Gentaur for Next week Delivery.

Description: Noggin belongs to a group of diffusible proteins which bind to ligands of the TGF-beta family and regulate their activity by inhibiting their access to signaling receptors. Noggin was originally identified as a BMP-4 antagonist whose action is critical for proper formation of the head and other dorsal structures. Consequently, Noggin has been shown to modulate the activities of other BMPs including BMP-2,-7,-13, and -14. Targeted deletion of Noggin in mice results in prenatal death and recessive phenotype displaying a severely malformed skeletal system. Conversely, transgenic mice over-expressing Noggin in mature osteoblasts display impaired osteoblastic differentiation, reduced bone formation, and severe osteoporosis.

Immunogen Sequence:E. coli expressed recombinant human Noggin

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Species Reactivities:Human

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Formulation:30 µg (0.5 mg/ml) affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.

Purification: Affinity purified

Application:Western blot

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Application And Usages:Western blotting (0.5-4 µg/ml). However, the optimal concentrations should be determined individually. Recombinant human Noggin (Cat.# 4675-20) can be used as a positive control.

Handling:The antibody solution should be gently mixed before use.