Neuregulin/Heregulin-1β Antibody

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SKU:
6650-30T
  • Neuregulin/Heregulin-1β Antibody
  • Neuregulin/Heregulin-1β Antibody
€89
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Description

Neuregulin/Heregulin-1β Antibodyis available at Gentaur for Next week Delivery.

Description: Neuregulin/Heregulin is a family of structurally related polypeptide growth factors derived from alternatively spliced genes (NRG1, NRG2, NRG3 and NRG4). To date, there are over 14 soluble and transmembrane proteins derived from the NRG1 gene. Proteolytic processing of the extracellular domain of the transmembrane NRG1 isoforms release soluble growth factors. HRG1-β1 contains an Ig domain and an EGF-like domain that is necessary for direct binding to receptor tyrosine kinases erb3 and erb4. This binding induces erb3 and erb4 heterodimerization with erb2, stimulating intrinsic kinase activity, which leads to tyrosine phosphorylation. Although HRG1-β1 biological effects is still unclear, it has been found to promote motility and invasiveness of breast cancer cells which may also involve up-regulation of expression and function of the autocrine motility-promoting factor (AMF). Recombinant human Heregulin-β1 (HRG1-β1) is a 7.5 kDa polypeptide consisting of only the EGF domain of Heregulin-β1 (65 amino acid residues).

Immunogen Sequence:Recombinant protein Heregulin-1 beta (177-241 aa) (BV-M66)

Target Alternative Name:NGR beta 1, Heregulin, HRG 1beta, Neuregulin

Species Reactivities:Human

Tag Line:Polyclonal Antibody to detect Heregulin-1β in human samples

Formulation:0.5 mg/ml in PBS (pH 7.2) containing 30% glycerol, 0.5% BSA, 5 mM EDTA and 0.03% proclin

Purification: Affinity Purified Antibody

Application:Western blot

Positive Control:Western blot: Recombinant protein

Application And Usages:Western blot: ~1:200

Handling:The antibody solution should be gently mixed before use.

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Additional Information

Size:
30 μg
Antibody Target:
Heregulin 1 beta
Category:
Heregulin 1 beta
Lot Number:
9C316650
Host:
Rabbit
Antibody Type:
Polyclonal
Isotype:
Rabbit IgG
Accession Number:
Q15491
Gene Id:
3084
Concentration:
0.5 mg/ml
Appearance:
Colorless liquid
Form:
Liquid
Storage Condition:
-20 °C
Shipping Condition:
gel pack
Shelf Life:
12 months
Country of Animal Origin:
USA
Country of Manufacture:
USA
Usage:
For Research Use Only! Not to be used in humans.
Western Blot Verified:
Verified
Immunocytochemistry Verified:
Not Verified
Immunofluorescence Verified:
Not Verified
Immunoprecipitation Verified:
Not Verified
ELISA Verified:
Not Verified
ChIP Verified:
Not Verified
Flow Cytometry Verified:
Not Verified
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