N6-Methyladenosine Antibody

N6-Methyladenosine Antibodyis available at Gentaur for Next week Delivery.

Description: N6-methyladenosine (m6A), or methylation of the N6 position of adenosine is a posttranscriptional modification of RNA. Due to a lack of analytical methods, N6-methyladenosine is poorly understood, but new evidence suggests that it is a very common base modification and important physiological regulator. N6-methyladenosine is markedly increased throughout brain development, and is enriched near stop codons, microRNA-binding sites and UTRs, which indicates a fundamental role in the regulation of gene expression. N6-methyladenosine is also highly conserved between human and mouse. The regulation of m6A modifications in mRNA has been linked to disease, where fat mass and obesity-associated (FTO) has been has been reported to be a obesity risk gene. FTO is a m6A demethylase and polymorphisms that result in increased FTO expression are associated with increased body mass and risk of obesity.

Immunogen Sequence:This antibody is generated from rabbits immunized with a BSA conjugated N6-Methyladenosine (BV-N13-14).

Target Alternative Name:m6A

Species Reactivities:Mammalian samples

Tag Line:Polyclonal Antibody to detect N6-Methyladenosine in mammalian samples.

Formulation:30 µg (1 mg/ml) in PBS (prepared using DEPC-treated water) with 0.09% (W/V) sodium azide.

Purification: Protein A and immunogen affinity purified antibody

Application:Western blot, Dot Blot, Chromatin Immunoprecipitation (ChIP), RNA Binding Protein Immunoprecipitation (RIP).

Positive Control:Western blot: N6-Methyladenosine conjugated with BSA, Adenosine conjugated with BSA

Application And Usages:Western blot: 1-4 µg/ml. Dot Blot, Chromatin Immunoprecipitation (ChIP), RNA Binding Protein Immunoprecipitation (RIP).

Handling:The antibody solution should be gently mixed before use.