N-Cadherin Antibody (Clone # EPR1791-4)

N-Cadherin Antibody (Clone # EPR1791-4)is available at Gentaur for Next week Delivery.

Description: Thy1 is a GPI-anchored, developmentally regulated protein involved in various signaling cascades that mediate neurite outgrowth, T cell activation, tumor suppression, apoptosis, and fibrosis. It is highly expressed on the surface of adult neurons and is thought to play a role in modulating adhesive and migratory events, such as neurite extension. Decreased Thy1 expression is associated with the development of epithelial ovarian cancer, revealing its role as a putative tumor suppressor gene of human ovarian cancer. Thy1 knockout mice have impaired cutaneous immune responses and abnormal retinal development. Thy1 is epigenetically regulated or deregulated in some disease states, such as pulmonary fibrosis. The potentially reversible hypermethylation of the Thy1 promoter offers the possibility of novel therapeutic options in this disease.

Immunogen Sequence:A synthetic peptide corresponding to residues in the extracellular region of human N-Cadherin was used as an immunogen.

Target Alternative Name:CDH2, CDHN, NCAD, Cadherin-2, CDw325

Species Reactivities:Human, Mouse, Rat.

Tag Line:Monoclonal Antibody to detect N Cadherin in human samples.

Formulation:In 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Purification: N/A

Application:Western blot.

Positive Control:Western blot:Huvec, C6 and Hela cell lysates.

Application And Usages:WB: 1:1000 – 1:10000.

Handling:The antibody solution should be gently mixed before use.